Its construction dates back to the second half of the 16th century, although the Palace of the Marquises of Peña de los Enamorados has undergone various renovations and additions throughout its history.
The exterior features seven bays of openings, with grilles on the ground floor and balconies on the main floor, topped by an attic or loft, which was added later. The towers follow the Antequera style. Very little of the original interior layout remains due to the fire it suffered during the Spanish Civil War.
The Palace of the Marquises of Peña de los Enamorados is currently the headquarters of the Colegio de Nuestra Señora del Carmen in Antequera, Málaga.